It is common to confuse literature and systematic reviews because both are used to provide a summary of the existing literature or research on a specific topic. Despite this commonality, these two reviews vary significantly. The table below highlights the differences.
| Literature Review | Systematic Review | |
| Definition | Qualitatively summarizes evidence on a topic using informal or subjective methods to collect and interpret studies | High-level overview of primary research on a focused question that identifies, selects, synthesizes, and appraises all high quality research evidence to that question | 
| Goals | Provide summary or overview of topic | Answer a focused clinical question Eliminate bias | 
| Question | Can be a general topic or specific question | Clearly defined and answerable clinical question | 
| Components | Introduction Methods Discussion Conclusion Reference List | Pre-specified eligibility criteria Systematic search strategy Assessment of the validity of findings Interpretation and presentation of results Reference list | 
| Number of Authors | One or more | Three or more | 
| Timeline | Weeks to months | Months to years (average 18 months) | 
| Requirements | Understanding of topic Perform searches of one or more databases | Thorough knowledge of topic Perform searches of all relevant databases Statistical analysis resources (for meta-analysis) | 
| Value | Provides summary of literature on a topic | Connects practicing clinicians to high-quality evidence Supports evidence-based practice | 
Kysh, Lynn (2013). Difference between a systematic review and a literature review. figshare. Poster. https://doi.org/10.6084/m9.figshare.766364.v1